Reported outcome measures in degenerative cervical myelopathy: a systematic review
Authors
McHugh, Maire
Elgheriani, Ali
Tetreault, Lindsay A
Fehlings, Michael G
Publication Date
2016Journal Title
PLOS ONE
ISSN
1932-6203
Publisher
Public Library of Science
Language
English
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Davies, B., McHugh, M., Elgheriani, A., Kolias, A., Tetreault, L. A., Hutchinson, P., Fehlings, M. G., & et al. (2016). Reported outcome measures in degenerative cervical myelopathy: a systematic review. PLOS ONE https://doi.org/10.17863/CAM.438
Abstract
${\bf Object}$. Degenerative cervical myelopathy [DCM] is a disabling and increasingly prevalent group of diseases. Heterogeneous reporting of trial outcomes limits effective inter-study comparison and optimisation of treatment. This is recognised in many fields of healthcare research. The present study aims to assess the heterogeneity of outcome reporting in DCM as the premise for the development of a standardised reporting set.
${\bf Methods}$. A systematic review of MEDLINE and EMBASE databases, registered with PROSPERO (CRD42015025497) was conducted in accordance with PRISMA guidelines. Full text articles in English, with >50 patients (prospective) or >200 patients (retrospective), reporting outcomes of DCM were eligible.
${\bf Results}$. 108 studies, assessing 23,876 patients, conducted world-wide, were identified. Reported outcome themes included function (reported by 97, 90% of studies), complications (reported by 56, 52% of studies), quality of life (reported by 31, 29% of studies), pain (reported by 29, 27% of studies) and imaging (reported by 59, 55% of studies). Only 7 (6%) studies considered all of domains in a single publication. All domains showed variability in reporting.
${\bf Conclusions}$. Significant heterogeneity exists in the reporting of outcomes in DCM. The development of a consensus minimum dataset will facilitate future research synthesis.
Keywords
cervical, myelopathy, outcome measure, spondylosis, spondylotic, stenosis, disc herniation, Ossification Posterior Longitudinal Ligament, degeneration
Sponsorship
MRNK is supported by NIHR Clinician Scientist Award; PJAH holds a NIHR research professorship.
Funder references
MRC (MC_PC_12009)
Embargo Lift Date
2100-01-01
Identifiers
This record's DOI: https://doi.org/10.17863/CAM.438
This record's URL: https://www.repository.cam.ac.uk/handle/1810/256492
Rights
Licence:
http://www.rioxx.net/licenses/all-rights-reserved