Unravelling the complex mechanisms of transgenerational epigenetic inheritance.
Blake, Georgina Et
Watson, Erica D
Curr Opin Chem Biol
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Blake, G. E., & Watson, E. D. (2016). Unravelling the complex mechanisms of transgenerational epigenetic inheritance.. Curr Opin Chem Biol, 33 101-107. https://doi.org/10.1016/j.cbpa.2016.06.008
There are numerous benefits to elucidating how our environment affects our health: from a greater understanding of adaptation to disease prevention. Evidence shows that stressors we are exposed to during our lifetime might cause disease in our descendants. Transgenerational epigenetic inheritance involves the transmission of 'information' over multiple generations via the gametes independent of the DNA base sequence. Despite extensive research, the epigenetic mechanisms remain unclear. Analysis of model organisms exposed to environmental insults (e.g., diet manipulation, stress, toxin exposure) or carrying mutations in the epigenetic regulatory machinery indicates that inheritance of altered DNA methylation, histone modifications, or non-coding RNAs are key mechanisms. Tracking inherited epigenetic information and its effects for multiple generations is a significant challenge to overcome.
G.E.T.B. is supported by a studentship from the Wellcome Trust 4-year PhD programme in Developmental Mechanisms. E.D.W. is a Lister Research Prize fellow and was supported by an Isaac Newton Trust/Wellcome Trust ISSF/University of Cambridge joint research grant.
Lister Institute of Preventive Medicine
External DOI: https://doi.org/10.1016/j.cbpa.2016.06.008
This record's URL: https://www.repository.cam.ac.uk/handle/1810/256643
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