Continuous-Flow Synthesis and Derivatization of Aziridines through Palladium-Catalyzed C(sp 3 )−H Activation

Abstract

A continuous flow synthesis of aziridines via palladium-catalyzed C(sp$^{3}$)–H activation. The new flow reaction could be combined with a aziridine ring opening reaction to give highly functionalized aliphatic amines via a consecutive process. A predictive mechanistic model was developed and used to design the C–H activation flow process and illustrates an approach towards first-principles design based on novel catalytic reactions.