Continuous-Flow Synthesis and Derivatization of Aziridines through Palladium-Catalyzed C(sp 3 )−H Activation
Publication Date
2016-07-20Journal Title
Angewandte Chemie
ISSN
1433-7851
Publisher
Wiley
Volume
55
Issue
31
Pages
8878-8883
Language
English
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Zakrzewski, J., Smalley, A., Kabeshov, M., Gaunt, M., & Lapkin, A. (2016). Continuous-Flow Synthesis and Derivatization of Aziridines through Palladium-Catalyzed C(sp 3 )−H Activation. Angewandte Chemie, 55 (31), 8878-8883. https://doi.org/10.1002/ange.201602483
Abstract
A continuous‐flow synthesis of aziridines by palladium‐catalyzed C(sp3)−H activation is described. The new flow reaction could be combined with an aziridine‐ring‐opening reaction to give highly functionalized aliphatic amines through a consecutive process. A predictive mechanistic model was developed and used to design the C−H activation flow process and illustrates an approach towards first‐principles design based on novel catalytic reactions.
Sponsorship
We are grateful to the Department of Chemical Engineering and Biotechnology (J.Z.) and the EPSRC (A.P.S.) for studentships, and to the ERC and EPSRC (EP/100548X/1) for fellowships (M.J.G.). Mass spectroscopy data were acquired at the EPSRC UK National Mass Spectroscopy Facility at Swansea University
Funder references
EPSRC (EP/I00548X/1)
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1002/ange.201602483
This record's URL: https://www.repository.cam.ac.uk/handle/1810/256663
Rights
Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International