Switch-like surface binding of competing multivalent particles
Publication Date
2016-07-18Journal Title
The European Physical Journal Special Topics
ISSN
1951-6355
Publisher
Springer
Language
English
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Tito, N., & Frenkel, D. (2016). Switch-like surface binding of competing multivalent particles. The European Physical Journal Special Topics https://doi.org/10.1140/epjst/e2016-60119-6
Abstract
Multivalent particles competing for binding on the same surface can exhibit switch-like behaviour, depending on the concentration of receptors on the surface. When the receptor concentration is low, energy dominates the free energy of binding, and particles having a small number of strongly-binding ligands preferentially bind to the surface. At higher receptor concentrations, multivalent effects become significant, and entropy dominates the binding free energy; particles having many weakly-binding ligands preferentially bind to the surface. Between these two regimes there is a “switch-point”, at which the surface binds the two species of particles equally strongly. We demonstrate that a simple theory can account for this switch-like behaviour and present numerical calculations that support the theoretical predictions. We argue that binding selectivity based on receptor density, rather than identity, may have practical applications.
Relationships
Is supplemented by: https://doi.org/10.17863/CAM.582
Sponsorship
European Union Seventh Framework Programme (FP/2007-2013) European Research Council (Grant Agreement n. 607602 (“SASSYPOL”)), Engineering and Physical Sciences Research Council (Grant ID: EP/I001352/1)
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1140/epjst/e2016-60119-6
This record's URL: https://www.repository.cam.ac.uk/handle/1810/257021
Rights
Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International
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