Repository logo
 

Switch-like surface binding of competing multivalent particles

Published version
Peer-reviewed

Change log

Authors

Tito, NB 

Abstract

Multivalent particles competing for binding on the same surface can exhibit switch-like behaviour, depending on the concentration of receptors on the surface. When the receptor concentration is low, energy dominates the free energy of binding, and particles having a small number of strongly-binding ligands preferentially bind to the surface. At higher receptor concentrations, multivalent effects become significant, and entropy dominates the binding free energy; particles having many weakly-binding ligands preferentially bind to the surface. Between these two regimes there is a "switch-point", at which the surface binds the two species of particles equally strongly. We demonstrate that a simple theory can account for this switch-like behaviour and present numerical calculations that support the theoretical predictions. We argue that binding selectivity based on receptor density, rather than identity, may have practical applications.

Description

Keywords

cond-mat.soft, cond-mat.soft

Journal Title

European Physical Journal: Special Topics

Conference Name

Journal ISSN

1951-6355
1951-6401

Volume Title

Publisher

Springer Science and Business Media LLC
Sponsorship
European Union Seventh Framework Programme (FP/2007-2013) European Research Council (Grant Agreement n. 607602 (“SASSYPOL”)), Engineering and Physical Sciences Research Council (Grant ID: EP/I001352/1)
Relationships
Is supplemented by: