Obesity associated with increased brain age from midlife
Authors
Alexander-Bloch, Aaron F
Wagstyl, Konrad
Farooqi, Sadaf
Cam-CAN,
Publication Date
2016-07-27Journal Title
Neurobiology of Aging
ISSN
0197-4580
Publisher
Elsevier
Volume
47
Pages
63-70
Language
English
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Ronan, L., Alexander-Bloch, A. F., Wagstyl, K., Farooqi, S., Brayne, C., Tyler, L., Cam-CAN,, & et al. (2016). Obesity associated with increased brain age from midlife. Neurobiology of Aging, 47 63-70. https://doi.org/10.1016/j.neurobiolaging.2016.07.010
Abstract
Common mechanisms in aging and obesity are hypothesized to increase susceptibility to neurodegeneration, however, direct evidence in support of this hypothesis is lacking. We therefore performed a cross-sectional analysis of magnetic resonance image-based brain structure on a population-based cohort of healthy adults. Study participants were originally part of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) and included 527 individuals aged 20-87 years. Cortical reconstruction techniques were used to generate measures of whole-brain cerebral white-matter volume, cortical thickness, and surface area. Results indicated that cerebral white-matter volume in overweight and obese individuals was associated with a greater degree of atrophy, with maximal effects in middle-age corresponding to an estimated increase of brain age of 10 years. There were no similar body mass index-related changes in cortical parameters. This study suggests that at a population level, obesity may increase the risk of neurodegeneration.
Keywords
obesity, white-matter volume, structural MRI, population-based
Sponsorship
This work was supported by the Bernard Wolfe Health Neuroscience Fund and the Wellcome Trust (grant number RNAG/259). The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) research was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/H008217/1).
Funder references
Department of Health (via National Institute for Health Research (NIHR)) (unknown)
BBSRC (BB/H008217/1)
WELLCOME TRUST (103838/Z/14/Z)
Medical Research Council (MC_U105597119)
Wellcome Trust (093875/Z/10/Z)
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1016/j.neurobiolaging.2016.07.010
This record's URL: https://www.repository.cam.ac.uk/handle/1810/259968
Rights
Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International, Attribution 4.0 International
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