Activated prothrombin complex in the management of direct thrombin inhibitor-associated intracerebral haemorrhage.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Evans, NR
Besser, MW
Khadjooi, K
Abstract
Intracerebral haematoma expansion independently predicts poor functional outcome and mortality. Therefore, it is important to act quickly to arrest this expansion. Whilst a direct antidote to dabigatran remains in development, the use of factor VIII inhibitor bypassing activity may offer a practical strategy for arresting haemorrhage in individuals taking direct thrombin inhibitors.
Description
Keywords
Aged, Antithrombins, Blood Coagulation Factors, Cerebral Hemorrhage, Humans, Male, Treatment Outcome
Journal Title
QJM
Conference Name
Journal ISSN
1460-2725
1460-2393
1460-2393
Volume Title
Publisher
Oxford University Press (OUP)
Publisher DOI
Sponsorship
The Dunhill Medical Trust (None)
NRE is supported by a Research Training Fellowship from The Dunhill Medical Trust [grant number RTF44/0114].