Transition states and cell fate decisions in epigenetic landscapes
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Publication Date
2016-09-12Journal Title
Nature Reviews Genetics
ISSN
1471-0056
Publisher
Nature Publishing Group
Volume
17
Pages
693-703
Language
English
Type
Article
This Version
AM
Metadata
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Moris, N., Correia Antunes Pina, C. P., & Martinez-Arias, A. (2016). Transition states and cell fate decisions in epigenetic landscapes. Nature Reviews Genetics, 17 693-703. https://doi.org/10.1038/nrg.2016.98
Abstract
Waddington’s epigenetic landscape is an abstract metaphor frequently used to represent the relationship between gene activity and cell fates during development. Over the past few years, it has become a useful framework for interpreting results from single-cell transcriptomics experiments. It has led to the proposal that, during fate transitions, cells experience smooth, continuous progressions of global transcriptional activity, which can be captured by (pseudo) temporal dynamics. Here, focusing strictly on the fate decision events, we suggest an alternative view: that fate transitions occur in a discontinuous, stochastic manner whereby signals modulate the probability of the transition events.
Keywords
development, differentiation, regulatory networks, transcriptomics
Sponsorship
Kay Kendall Leukaemia Fund
Funder references
Kay Kendall Leukaemia Fund (KKL888)
Identifiers
External DOI: https://doi.org/10.1038/nrg.2016.98
This record's URL: https://www.repository.cam.ac.uk/handle/1810/260715
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