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Transition states and cell fate decisions in epigenetic landscapes.

Accepted version
Peer-reviewed

Type

Article

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Authors

Correia Antunes Pina, Cristina Pina  ORCID logo  https://orcid.org/0000-0002-2575-6301
Arias, Alfonso Martinez 

Abstract

Waddington's epigenetic landscape is an abstract metaphor frequently used to represent the relationship between gene activity and cell fates during development. Over the past few years, it has become a useful framework for interpreting results from single-cell transcriptomics experiments. It has led to the proposal that, during fate transitions, cells experience smooth, continuous progressions of global transcriptional activity, which can be captured by (pseudo)temporal dynamics. Here, focusing strictly on the fate decision events, we suggest an alternative view: that fate transitions occur in a discontinuous, stochastic manner whereby signals modulate the probability of the transition events.

Description

Keywords

Animals, Cell Differentiation, Cell Lineage, Computational Biology, Epigenesis, Genetic, Humans, Models, Genetic, Stochastic Processes

Journal Title

Nat Rev Genet

Conference Name

Journal ISSN

1471-0056
1471-0064

Volume Title

17

Publisher

Springer Science and Business Media LLC
Sponsorship
Kay Kendall Leukaemia Fund (KKL888)
Kay Kendall Leukaemia Fund