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Collagen: a network for regenerative medicine.

Published version
Peer-reviewed

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Authors

Pawelec, KM 
Best, SM 
Cameron, RE 

Abstract

The basic building block of the extra-cellular matrix in native tissue is collagen. As a structural protein, collagen has an inherent biocompatibility making it an ideal material for regenerative medicine. Cellular response, mediated by integrins, is dictated by the structure and chemistry of the collagen fibers. Fiber formation, via fibrillogenesis, can be controlled in vitro by several factors: pH, ionic strength, and collagen structure. After formation, fibers are stabilized via cross-linking. The final bioactivity of collagen scaffolds is a result of both processes. By considering each step of fabrication, scaffolds can be tailored for the specific needs of each tissue, improving their therapeutic potential.

Description

Keywords

0601 Biochemistry and Cell Biology, Regenerative Medicine, Musculoskeletal, 1.1 Normal biological development and functioning

Journal Title

J Mater Chem B

Conference Name

Journal ISSN

2050-750X
2050-750X

Volume Title

4

Publisher

Royal Society of Chemistry (RSC)
Sponsorship
European Research Council (320598)
REC acknowledges financial assistance from European Research Council (ERC) Advanced Grant 320598 3D-E.