Sickle cell anemia (SCA) is one of the commonest severe inherited disorders affecting millions worldwide. Complications are extensive although severity varies markedly. Renal damage [or sickle cell nephropathy (SCN)] occurs in approximately one-third of SCA children1,2 and a significant number develop renal failure as adults.3 It is not yet possible to predict which children will develop SCN and would, therefore, benefit from earlier, more aggressive management