Epigenetic determinants of metastasis.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Patel, Saroor A
Vanharanta, Sakari https://orcid.org/0000-0001-5619-7963
Abstract
Genetic analyses of cancer progression in patient samples and model systems have thus far failed to identify specific mutational drivers of metastasis. Yet, at least in experimental systems, metastatic cancer clones display stable traits that can facilitate progression through the many steps of metastasis. How cancer cells establish and maintain the transcriptional programmes required for metastasis remains mostly unknown. Emerging evidence suggests that metastatic traits may arise from epigenetically altered transcriptional output of the oncogenic signals that drive tumour initiation and early progression. Molecular dissection of such mechanisms remains a central challenge for a comprehensive understanding of the origins of metastasis.
Description
Keywords
Cancer, Epigenetic, Metastasis
Journal Title
Mol Oncol
Conference Name
Journal ISSN
1574-7891
1878-0261
1878-0261
Volume Title
Publisher
Wiley
Publisher DOI
Sponsorship
Medical Research Council (MC_UU_12022/7)
Medical Research Council