Show simple item record

dc.contributor.authorSchmidt, Casperen
dc.contributor.authorMorris, Laurelen
dc.contributor.authorKvamme, Timo Len
dc.contributor.authorHall, Paulaen
dc.contributor.authorBirchard, Thaddeusen
dc.contributor.authorVoon, Valerieen
dc.date.accessioned2016-12-13T11:12:23Z
dc.date.available2016-12-13T11:12:23Z
dc.date.issued2017-03en
dc.identifier.issn1065-9471
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/261538
dc.description.abstract$\textit{Background:}$ Compulsive sexual behaviors (CSB) are relatively common and associated with significant personal and social dysfunction. The underlying neurobiology is still poorly understood. The present study examines brain volumes and resting state functional connectivity in CSB compared with matched healthy volunteers (HV). $\textit{Methods:}$ Structural MRI (MPRAGE) data were collected in 92 subjects (23 CSB males and 69 age-matched male HV) and analyzed using voxel-based morphometry. Resting state functional MRI data using multi-echo planar sequence and independent components analysis (ME-ICA) were collected in 68 subjects (23 CSB subjects and 45 age-matched HV). $\textit{Results:}$ CSB subjects showed greater left amygdala gray matter volumes (small volume corrected, Bonferroni adjusted $P$ < 0.01) and reduced resting state functional connectivity between the left amygdala seed and bilateral dorsolateral prefrontal cortex (whole brain, cluster corrected FWE $P$ < 0.05) compared with HV. $\textit{Conclusions:}$ CSB is associated with elevated volumes in limbic regions relevant to motivational salience and emotion processing, and impaired functional connectivity between prefrontal control regulatory and limbic regions. Future studies should aim to assess longitudinal measures to investigate whether these findings are risk factors that predate the onset of the behaviors or are consequences of the behaviors.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.language.isoenen
dc.publisherWiley
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleCompulsive sexual behavior: Prefrontal and limbic volume and interactions.en
dc.typeArticle
prism.endingPage1190
prism.publicationDate2017en
prism.publicationNameHuman brain mappingen
prism.startingPage1182
prism.volume38en
dc.identifier.doi10.17863/CAM.6737
dcterms.dateAccepted2016-10-07en
rioxxterms.versionofrecord10.1002/hbm.23447en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-03en
dc.identifier.eissn1097-0193
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (093705/Z/10/Z)
pubs.funder-project-idMRC (G1000183)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)
cam.orpheus.successThu Jan 30 12:56:49 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International