Mammalian autophagy and the plasma membrane.
The FEBS journal
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Pavel, M., & Rubinsztein, D. (2017). Mammalian autophagy and the plasma membrane.. The FEBS journal, 284 672-679. https://doi.org/10.1111/febs.13931
Autophagy (literally "self-eating") is an evolutionarily conserved degradation process where cytoplasmic components are engulfed by vesicles called autophagosomes, which are then delivered to lysosomes, where their contents are degraded. Under stress conditions, such as starvation or oxidative stress, autophagy is upregulated in order to degrade macromolecules and restore the nutrient balance. The source of membranes that participate in the initial formation of phagophores is still incompletely understood and many intracellular structures have been shown to act as lipid donors, including the endoplasmic reticulum, Golgi, nucleus, mitochondria and the plasma membrane. Here we focus on the contributions of the plasma membrane to autophagosome biogenesis governed by ATG16L1 and ATG9A trafficking, and summarise the physiological and pathological implications of this macroautophagy route, from development and stem cell fate to neurodegeneration and cancer. This article is protected by copyright. All rights reserved.
Cell Membrane, Lysosomes, Mitochondria, Animals, Mammals, Humans, Membrane Proteins, Vesicular Transport Proteins, Endocytosis, Protein Transport, Oxidative Stress, Autophagy, Autophagy-Related Proteins, Autophagosomes
Wellcome Trust (095317/Z/11/Z)
Wellcome Trust (095317/Z/11/A)
EC FP7 MC ITN (264508)
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
EC FP7 CP (305121)
Addenbrooke's Charitable Trust (ACT) (PF15/DR/9342)
Federation of the European Biochemical Societies (FEBS) (unknown)
Wellcome Trust (100140/Z/12/Z)
External DOI: https://doi.org/10.1111/febs.13931
This record's URL: https://www.repository.cam.ac.uk/handle/1810/261752