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dc.contributor.authorYuan, Jianminen
dc.contributor.authorUsman, Ammaraen
dc.contributor.authorReid, Scott Aen
dc.contributor.authorKing, Kevin Fen
dc.contributor.authorPatterson, Andrewen
dc.contributor.authorGillard, Jonathanen
dc.contributor.authorGraves, Martinen
dc.date.accessioned2017-02-13T14:50:01Z
dc.date.available2017-02-13T14:50:01Z
dc.date.issued2017-04en
dc.identifier.issn0730-725X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/262484
dc.description.abstractPURPOSE: To develop a 3D black-blood T₂ mapping sequence with a combination of compressed sensing (CS) and parallel imaging (PI) for carotid wall imaging. MATERIALS AND METHODS: A 3D black-blood fast-spin-echo (FSE) sequence for T₂ mapping with CS and PI was developed and validated. Phantom experiments were performed to assess T₂ accuracy using a Eurospin Test Object, with different combination of CS and PI acceleration factors. A 2D multi-echo FSE sequence was used as a reference to evaluate the accuracy. The concordance correlation coefficient and Bland-Altman statistics were calculated. Twelve volunteers were scanned twice to determine the repeatability of the sequence and the intraclass correlation coefficient (ICC) was reported. Wall-lumen sharpness was calculated for different CS and PI combinations. Six patients with carotid stenosis >50% were scanned with optimised sequence. The T₂ maps were compared with multi-contrast images. RESULTS: Phantom scans showed good correlation in T₂ measurement between current and reference sequence (r=0.991). No significant difference was found between different combination of CS and PI accelerations (p=0.999). Volunteer scans showed good repeatability of T₂ measurement (ICC: 0.93, 95% CI 0.84-0.97). The mean T₂ of the healthy wall was 48.0±9.5ms. Overall plaque T₂ values from patients were 54.9±12.2ms. Recent intraplaque haemorrhage and fibrous tissue have higher T₂ values than the mean plaque T₂ values (88.1±6.8ms and 62.7±9.3ms, respectively). CONCLUSION: This study demonstrates the feasibility of combining CS and PI for accelerating 3D T₂ mapping in the carotid artery, with accurate T₂ measurements and good repeatability.
dc.description.sponsorshipThe project was supported by the Addenbrooke's Charitable Trust and the NIHR comprehensive Biomedical Research Centre award to Cambridge University Hospitals NHS Foundation Trust in partnership with the University of Cambridge.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.language.isoenen
dc.publisherElsevier BV
dc.subjectCarotid Arteriesen
dc.subjectHumansen
dc.subjectCarotid Stenosisen
dc.subjectImaging, Three-Dimensionalen
dc.subjectMagnetic Resonance Imagingen
dc.subjectFeasibility Studiesen
dc.subjectReproducibility of Resultsen
dc.subjectPhantoms, Imagingen
dc.subjectImage Processing, Computer-Assisteden
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectYoung Adulten
dc.titleThree-dimensional black-blood T2 mapping with compressed sensing and data-driven parallel imaging in the carotid artery.en
dc.typeArticle
prism.endingPage69
prism.publicationDate2017en
prism.publicationNameMagnetic resonance imagingen
prism.startingPage62
prism.volume37en
dc.identifier.doi10.17863/CAM.7746
dcterms.dateAccepted2016-11-20en
rioxxterms.versionofrecord10.1016/j.mri.2016.11.014en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-04en
dc.contributor.orcidGillard, Jonathan [0000-0003-4787-8091]
dc.contributor.orcidGraves, Martin [0000-0003-4327-3052]
dc.identifier.eissn1873-5894
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEC FP7 CP (224297)
pubs.funder-project-idBritish Heart Foundation (RG/10/007/28300)
pubs.funder-project-idBritish Heart Foundation (PG/11/74/29100)
pubs.funder-project-idTCC (NIHR/CS/009/011)
rioxxterms.freetoread.startdate2017-11-22


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