Murine Electrophysiological Models of Cardiac Arrhythmogenesis
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Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological processes underlying excitable activity and their tissue propagation as coherent wavefronts from the primary sinoatrial node pacemaker, through the atria, conducting structures and ventricular myocardium. These physiological events are driven by interacting, voltage-dependent, processes of activation, inactivation, and recovery in the ion channels present in cardiomyocyte membranes. Generation and conduction of these events are further modulated by intracellular Ca
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1522-1210
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Medical Research Council (MR/M001288/1)
Wellcome Trust (105727/Z/14/Z)