Accommodating informative dropout and death: a joint modelling approach for longitudinal and semi-competing risks data.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Li, Qiuju
Abstract
Both dropout and death can truncate observation of a longitudinal outcome. Since extrapolation beyond death is often not appropriate, it is desirable to obtain the longitudinal outcome profile of a population given being alive. We propose a new likelihood-based approach to accommodating informative dropout and death by jointly modelling the longitudinal outcome and semi-competing event times of dropout and death, with an important feature that the conditional longitudinal profile of being alive can be conveniently obtained in a closed form. We use proposed methods to estimate different longitudinal profiles of CD4 count for patients from the HIV Epidemiology Research Study.
Description
Keywords
Joint models, Missing data, Shared parameter models, Survival analysis
Journal Title
J R Stat Soc Ser C Appl Stat
Conference Name
Journal ISSN
0035-9254
1467-9876
1467-9876
Volume Title
Publisher
Oxford University Press (OUP)
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Sponsorship
MRC (unknown)
MRC (unknown)
Medical Research Council (MR/M025152/1)
MRC (unknown)
Medical Research Council (MR/M025152/1)