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Accommodating informative dropout and death: a joint modelling approach for longitudinal and semi-competing risks data.

Published version
Peer-reviewed

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Authors

Abstract

Both dropout and death can truncate observation of a longitudinal outcome. Since extrapolation beyond death is often not appropriate, it is desirable to obtain the longitudinal outcome profile of a population given being alive. We propose a new likelihood-based approach to accommodating informative dropout and death by jointly modelling the longitudinal outcome and semi-competing event times of dropout and death, with an important feature that the conditional longitudinal profile of being alive can be conveniently obtained in a closed form. We use proposed methods to estimate different longitudinal profiles of CD4 count for patients from the HIV Epidemiology Research Study.

Description

Keywords

Joint models, Missing data, Shared parameter models, Survival analysis

Journal Title

J R Stat Soc Ser C Appl Stat

Conference Name

Journal ISSN

0035-9254
1467-9876

Volume Title

Publisher

Oxford University Press (OUP)
Sponsorship
MRC (unknown)
MRC (unknown)
Medical Research Council (MR/M025152/1)