Cobalt-catalysed C–H carbonylative cyclisation of aliphatic amides
Royal Society of Chemistry
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Williamson, P., Galván, A., & Gaunt, M. (2017). Cobalt-catalysed C–H carbonylative cyclisation of aliphatic amides. Chemical Science https://doi.org/10.1039/C6SC05581H
A cobalt-catalysed C–H carbonylation of aliphatic carboxamide derivatives is described, employing commercially available Co(II)-salts in the presence of a silver oxidant. This operationally simple process utilises an atmospheric pressure of CO and generates a range of substituted succinimide products bearing diverse functional groups that can be successfully accessed via this methodology.
We are grateful to the Herchel Smith Foundation for a scholarship (P. W.) and the Royal Society (Wolfson Merit Award, M. J. G) and the EPSRC (EP/100548X/1) and ERC (ERC-StG-259711) for Fellowships (M. J. G). Mass spectrometry data were acquired at the EPSRC UK National Mass Spectrometry Facility at Swansea University.
Royal Society (wm140104)
European Research Council (259711)
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External DOI: https://doi.org/10.1039/C6SC05581H
This record's URL: https://www.repository.cam.ac.uk/handle/1810/262903
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