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dc.contributor.authorKawasaki, Fumikoen
dc.contributor.authorMurat, Pen
dc.contributor.authorLi, Zen
dc.contributor.authorSantner, Ten
dc.contributor.authorBalasubramanian, Shankaren
dc.date.accessioned2017-03-14T17:49:30Z
dc.date.available2017-03-14T17:49:30Z
dc.identifier.issn1359-7345
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/263112
dc.description.abstractWe report the synthesis of a 5-formyl-2'-deoxyuridine (5fU) phosphoramidite and the preparation of oligonucleotides comprising all known, naturally observed eukaryotic thymidine modifications. Biophysical characterization of the synthetic oligonucleotides indicates that 5fU, but not the other T-derivatives, can alter DNA structures.
dc.description.sponsorshipThis work was supported by the following grants: the Wellcome Trust (099232/Z/12/Z), Cancer Research UK (C14303/A17197), ERC Advanced grant (PM), Herchel Smith Funding and A*STAR (ZL).
dc.languageengen
dc.language.isoenen
dc.publisherRoyal Society of Chemistry
dc.titleSynthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides.en
dc.typeArticle
prism.endingPage1392
prism.publicationNameChemical Communicationsen
prism.startingPage1389
prism.volume53en
dc.identifier.doi10.17863/CAM.8415
dcterms.dateAccepted2016-12-28en
rioxxterms.versionofrecord10.1039/c6cc08670een
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-12-28en
dc.contributor.orcidBalasubramanian, Shankar [0000-0002-0281-5815]
dc.identifier.eissn1364-548X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (099232/Z/12/Z)
cam.issuedOnline2017-01-04en
rioxxterms.freetoread.startdate2018-01-04


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