Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis
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Although many aspects of blood production are well understood, the spatial organization of myeloid differentiation in the bone marrow remains unknown. Here we use imaging to track granulocyte/macrophage progenitor (GMP) behaviour in mice during emergency and leukaemic myelopoiesis. In the steady state, we find individual GMPs scattered throughout the bone marrow. During regeneration, we observe expanding GMP patches forming defined GMP clusters, which, in turn, locally differentiate into granulocytes. The timed release of important bone marrow niche signals (SCF, IL-1β, G-CSF, TGFβ and CXCL4) and activation of an inducible
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1476-4687
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Leukaemia & Lymphoma Research (12029)
Medical Research Council (MC_PC_12009)
Medical Research Council (MR/M008975/1)