Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes
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Mohapatra, S., Wilson, Z., Roy, S., & Ley, S. (2017). Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes. Tetrahedron, 73 (14), 1812-1819. https://doi.org/10.1016/j.tet.2017.02.026
Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf)3 catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction times allowing for rapid investigation of scope with straightforward work up facilitating product isolation.
alkylation, scandium triflate, bis(indolyl)methanes, flow, catalysis
We gratefully acknowledge funding from the British Council, UK and DST-Inspire, India (Newton-Bhabha Ph.D Placement Programme, SSM) and the Engineering and Physical Sciences Research Council (grants EP/K009494/1 and EP/K039520/1).
British Council (13)
External DOI: https://doi.org/10.1016/j.tet.2017.02.026
This record's URL: https://www.repository.cam.ac.uk/handle/1810/264029
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/