Diverse integrin adhesion stoichiometries caused by varied actomyosin activity
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Cells in an organism are subjected to numerous sources of external and internal forces, and are able to sense and respond to these forces. Integrin-mediated adhesion links the extracellular matrix outside cells to the cytoskeleton inside, and participates in sensing, transmitting and responding to forces. While integrin adhesion rapidly adapts to changes in forces in isolated migrating cells, it is not known whether similar or more complex responses occur within intact, developing tissues. Here, we studied changes in integrin adhesion composition upon different contractility conditions in
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2046-2441
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Wellcome Trust (092096/Z/10/Z)
Wellcome Trust (086451/Z/08/Z)
Wellcome Trust (069943/Z/02/Z)
Biotechnology and Biological Sciences Research Council (BB/D526102/1)
Cancer Research Uk (None)