DESolution of CD and CB Macrocycles.
Chemistry (Weinheim an der Bergstrasse, Germany)
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McCune, J., Kunz, S., Olesińska, M., & Scherman, O. (2017). DESolution of CD and CB Macrocycles.. Chemistry (Weinheim an der Bergstrasse, Germany), 23 8601-8604. https://doi.org/10.1002/chem.201701275
Supramolecular chemistry utilizing the macrocyclic hosts cyclodextrins (CDs) and cucurbit[n]urils (CB[n]s) is traditionally carried out in aqueous media, however, their solubility is typically poor, especially the family of cucurbit[n]urils. Through derivitization of these macrocycles their solubility can be augmented to enable enhanced solubility in water and in some organic solvents. The increase in solubility of these derivitized macrocycles allows for their use in a wider range of chemical environments and giving rise to myriad potential applications. We report the dissolution of parent CDs (α-, β- and γ-) and CB[n]s (n= 6-8) in a in deep eutectic solvents (DES) showing dramatic enhanced solubility of the larger species in both families, CB and CB as well as β- and γ- CD, respectively. Furthermore, we show that the host-guest properties are maintained in this new solvation medium.
This research was supported by the European Union (European Research Council Starting Grants ASPiRe 240629 (OAS), EPSRC departmental PhD studentship (EP/K503009/1 (JAM)) and Marie Curie FP7 SASSYPOL ITN (607602) programme (OAS & MO).
European Research Council (240629)
European Commission (607602)
External DOI: https://doi.org/10.1002/chem.201701275
This record's URL: https://www.repository.cam.ac.uk/handle/1810/264662