Properties of the tapasin homologue TAPBPR
Current Opinion in Immunology
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Neerincx, A., & Boyle, L. (2017). Properties of the tapasin homologue TAPBPR. Current Opinion in Immunology, 46 97-102. https://doi.org/10.1016/j.coi.2017.04.008
The presentation of antigenic peptides by MHC class I molecules plays a vital role in generating T cell responses against infection and cancer. Over the last two decades the central role of tapasin as a peptide editor that influences the loading and optimisation of peptides onto MHC class I molecules has been extensively characterised. Recently, it has become evident that the tapasin-related protein, TAPBPR, functions as a second peptide editor which influences the peptides displayed by MHC class I molecules. Here, we review the discovery of TAPBPR and current understanding of this novel protein in relation to its closest homologue tapasin.
This work was funded by a Wellcome Trust Senior Research Fellowship 104647/Z/14/Z.
Wellcome Trust (085038/Z/08/Z)
WELLCOME TRUST (104647/Z/14/Z)
External DOI: https://doi.org/10.1016/j.coi.2017.04.008
This record's URL: https://www.repository.cam.ac.uk/handle/1810/265016
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