Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice
Frontiers in Immunology
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Gaynor, L., & Colucci, F. (2017). Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice. Frontiers in Immunology, 8 (467) https://doi.org/10.3389/fimmu.2017.00467
Our understanding of development and function of natural killer (NK) cells has progressed significantly in recent years. However, exactly how uterine NK (uNK) cells develop and function is still unclear. To help investigators that are beginning to study tissue NK cells, we summarize in this review our current knowledge of the development and function of uNK cells, and what is yet to be elucidated. We compare and contrast the biology of human and mouse uNK cells in the broader context of the biology of innate lymphoid cells and with reference to peripheral NK cells. We also review how uNK cells may regulate trophoblast invasion and uterine spiral arterial remodeling in human and murine pregnancy.
arterial remodeling, placenta, pregnancy, trophoblast, uterine innate lymphoid cells, uterine natural killer cells
The authors would like to thank Ashley Moffett and Jens Kieckbusch for critically reading the manuscript and all members of the laboratory which is funded by the Wellcome Trust and the Centre for Trophoblast Research. LMG was funded by fellowships from the British Heart Foundation (FS/12/4/29254) and the Centre for Trophoblast Research.
Wellcome Trust (094073/Z/10/Z)
British Heart Foundation (None)
Wellcome Trust (200841/Z/16/Z)
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External DOI: https://doi.org/10.3389/fimmu.2017.00467
This record's URL: https://www.repository.cam.ac.uk/handle/1810/265392
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