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Arf GTPase interplay with Rho GTPases in regulation of the actin cytoskeleton

Accepted version
Peer-reviewed

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Type

Article

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Authors

Singh, V 
Davidson, AC 
Hume, PJ 
Humphreys, D 
Koronakis, Vassilis  ORCID logo  https://orcid.org/0000-0002-1353-1092

Abstract

The Arf and Rho subfamilies of small GTPases are nucleotide-dependent molecular switches that act as master regulators of vesicular trafficking and the actin cytoskeleton organization. Small GTPases control cell processes with high fidelity by acting through distinct repertoires of binding partners called effectors. While we understand a great deal about how these GTPases act individually, relatively little is known about how they cooperate, especially in the control of effectors. This review highlights how Arf GTPases collaborate with Rac1 to regulate actin cytoskeleton dynamics at the membrane via recruiting and activating the Wave Regulatory Complex (WRC), a Rho effector that underpins lamellipodia formation and macropinocytosis. This provides insight into Arf regulation of the actin cytoskeleton, whilst putting the spotlight on small GTPase cooperation with emerging evidence of its importance in fundamental cell biology and interactions with pathogenic bacteria.

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Keywords

Actin cytoskeleton, Arf and Rho GTPases, EPEC and bacterial effector proteins, Salmonella, Wave regulatory complex

Journal Title

Small GTPases

Conference Name

Journal ISSN

2154-1248
2154-1256

Volume Title

Publisher

Taylor & Francis
Sponsorship
Medical Research Council (MR/M011771/1)
Medical Research Council (MR/L008122/1)
Wellcome Trust (101828/Z/13/Z)
Medical Research Council (MR/K000888/1)