Mitochondria in neuroinflammation - Multiple sclerosis (MS), leber hereditary optic neuropathy (LHON) and LHON-MS.
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Bargiela, D., & Chinnery, P. (2017). Mitochondria in neuroinflammation - Multiple sclerosis (MS), leber hereditary optic neuropathy (LHON) and LHON-MS.. Neuroscience Letters https://doi.org/10.1016/j.neulet.2017.06.051
Mitochondrial dysfunction is associated with neuroinflammation and neurodegenerative disease, but its role as a driver in these processes is uncertain. Understanding the pathogenesis of inherited mitochondrial disorders may help us to uncover mechanisms involved during acquired mitochondrial dysfunction. We review the mechanisms of mitochondrial dysfunction in Leber's hereditary optic neuropathy and multiple sclerosis and discuss shared clinical and molecular features in both conditions. Targeting mitochondrial pathways involved in inflammation or apoptosis may be a possible therapeutic approach in multiple sclerosis.
Harding’s disease, LHON-MS, Leber’s hereditary optic neuropathy, Mitochondria, Multiple sclerosis, Neurodegeneration, Neuroinflammation
Department of Health (via National Institute for Health Research (NIHR)) (unknown)
WELLCOME TRUST (101876/Z/13/Z)
WELLCOME TRUST (101876/B/13/A)
Cambridge University Hospitals NHS Foundation Trust (CUH) (3819-1617-17)
Department of Health (via Newcastle University) (BH091682-RG81903)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
External DOI: https://doi.org/10.1016/j.neulet.2017.06.051
This record's URL: https://www.repository.cam.ac.uk/handle/1810/265773