Crystallization of Amphiphilic DNA C-Stars
American Chemical Society
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Brady, R., Brooks, N., Cicuta, P., & Di Michele, L. (2017). Crystallization of Amphiphilic DNA C-Stars. Nano Letters, 17 (5), 3276-3281. https://doi.org/10.1021/acs.nanolett.7b00980
Many emerging technologies require materials with well-defined three-dimensional nanoscale architectures. Production of these structures is currently underpinned by self-assembling amphiphilic macromolecules or engineered all-DNA building blocks. Both of these approaches produce restricted ranges of crystal geometries due to synthetic amphiphiles' simple shape and limited specificity, or the technical difficulties in designing space-filling DNA motifs with targeted shapes. We have overcome these limitations with amphiphilic DNA nanostructures, or "C-Stars", that combine the design freedom and facile functionalization of DNA-based materials with robust hydrophobic interactions. C-Stars self-assemble into single crystals exceeding 40 μm in size with lattice parameters exceeding 20 nm.
DNA crystallization, hydrophobic interactions, amphiphilic molecules, self-assembly, single crystals, DNA nanotechnology
Is supplemented by: https://doi.org/10.17863/CAM.9031
L.D.M., P.C., and N.J.B. acknowledge support from the EPSRC Programme Grant CAPITALS number EP/J017566/1. L.D.M. acknowledges support from the Oppenheimer Fund, Emmanuel College Cambridge, the Leverhulme Trust, and the Isaac Newton Trust through an Early Career Fellowship (ECF-2015- 494). R.A.B. acknowledges support from the EPSRC CDT in Nanoscience and Nanotechnology (NanoDTC), grant number EP/L015978/1. We acknowledge Diamond Light Source for provision of synchrotron beamtime (SM14217, SM15530, and SM15030), and we would like to thank Andy Smith for assistance in operating beamline I22.
External DOI: https://doi.org/10.1021/acs.nanolett.7b00980
This record's URL: https://www.repository.cam.ac.uk/handle/1810/266856
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
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