Crystallization of Amphiphilic DNA C-Stars
American Chemical Society
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Brady, R., Brooks, N., Cicuta, P., & Di Michele, L. (2017). Crystallization of Amphiphilic DNA C-Stars. Nano Letters, 17 (5), 3276-3281. https://doi.org/10.1021/acs.nanolett.7b00980
Many emerging technologies require materials with well-defined three-dimensional nanoscale architectures. Production of these structures is currently underpinned by self-assembling amphiphilic macromolecules or engineered all-DNA building blocks. Both of these approaches produce restricted ranges of crystal geometries due to synthetic amphiphiles' simple shape and limited specificity, or the technical difficulties in designing space-filling DNA motifs with targeted shapes. We have overcome these limitations with amphiphilic DNA nanostructures, or "C-Stars", that combine the design freedom and facile functionalization of DNA-based materials with robust hydrophobic interactions. C-Stars self-assemble into single crystals exceeding 40 μm in size with lattice parameters exceeding 20 nm.
DNA crystallization, hydrophobic interactions, amphiphilic molecules, self-assembly, single crystals, DNA nanotechnology
Is supplemented by: https://doi.org/10.17863/CAM.9031
L.D.M., P.C., and N.J.B. acknowledge support from the EPSRC Programme Grant CAPITALS number EP/J017566/1. L.D.M. acknowledges support from the Oppenheimer Fund, Emmanuel College Cambridge, the Leverhulme Trust, and the Isaac Newton Trust through an Early Career Fellowship (ECF-2015- 494). R.A.B. acknowledges support from the EPSRC CDT in Nanoscience and Nanotechnology (NanoDTC), grant number EP/L015978/1. We acknowledge Diamond Light Source for provision of synchrotron beamtime (SM14217, SM15530, and SM15030), and we would like to thank Andy Smith for assistance in operating beamline I22.
Engineering and Physical Sciences Research Council (EP/L015978/1)
External DOI: https://doi.org/10.1021/acs.nanolett.7b00980
This record's URL: https://www.repository.cam.ac.uk/handle/1810/266856
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
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