Deconstructing and reconstructing the mouse and human early embryo.
Nat Cell Biol
Springer Science and Business Media LLC
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Shahbazi, M. N., & Zernicka-Goetz, M. (2018). Deconstructing and reconstructing the mouse and human early embryo.. Nat Cell Biol, 20 (8), 878-887. https://doi.org/10.1038/s41556-018-0144-x
The emergence of form and function during mammalian embryogenesis is a complex process that involves multiple regulatory levels. The foundations of the body plan are laid throughout the first days of post-implantation development as embryonic stem cells undergo symmetry breaking and initiate lineage specification, in a process that coincides with a global morphological reorganization of the embryo. Here, we review experimental models and how they have shaped our current understanding of the post-implantation mammalian embryo.
Cells, Cultured, Animals, Humans, Mice, Embryo Research, Signal Transduction, Gene Expression Regulation, Developmental, Cell Lineage, Morphogenesis, Gestational Age, History, 20th Century, History, 21st Century, Embryo, Mammalian, Stem Cell Research, Human Embryonic Stem Cells, Mouse Embryonic Stem Cells
European Research Council (669198) Wellcome Trust (098287/Z/12/Z) Early Career Leverhulme Trust fellowship.
Wellcome Trust (098287/Z/12/Z)
European Research Council (669198)
Isaac Newton Trust (17.08(p))
Leverhulme Trust (ECF-2017-285)
External DOI: https://doi.org/10.1038/s41556-018-0144-x
This record's URL: https://www.repository.cam.ac.uk/handle/1810/279825