A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles

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Authors
  Ley, Steven
Godineau, Edouard
Battilocchio, Claudio
Lehmann, Matthias
  Labes, Ricardo
Birnoschi, letitia
Subramanian, Srinivas
Journal Title
OPRD
Type
Article
Metadata
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Citation
Ley, S., Godineau, E., Battilocchio, C., Lehmann, M., Labes, R., Birnoschi, l., Subramanian, S., et al. (2018). A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles. OPRD https://doi.org/10.1021/acs/oprd.8b00095
Abstract
We report a strategy designed for the rapid and convergent assembly of C4-oxime substituted thiazoles. Our approach relied on 3-bromo-2-oxopropanal O-methyl oxime as a key building block. In particular, we describe a multistep continuous synthesis of this intermediate and demonstrate the advantages of our set-up upon scaling up.
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Identifiers
External DOI: https://doi.org/10.1021/acs/oprd.8b00095
This record's URL: https://www.repository.cam.ac.uk/handle/1810/279948
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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