A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles
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Authors
Godineau, Edouard
Battilocchio, Claudio
Lehmann, Matthias
Birnoschi, letitia
Subramanian, Srinivas
Prasanna, CS
Gorde, Amol
Kalbagh, Mahesh
Khade, Vivek
Scherrer, Anton
O'Sullivan, Anthony Cornelius
Journal Title
OPRD
Type
Article
Metadata
Show full item recordCitation
Ley, S., Godineau, E., Battilocchio, C., Lehmann, M., Labes, R., Birnoschi, l., Subramanian, S., et al. (2018). A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles. OPRD https://doi.org/10.1021/acs/oprd.8b00095
Abstract
We report a strategy designed for the rapid and convergent assembly of C4-oxime substituted thiazoles. Our approach relied on 3-bromo-2-oxopropanal O-methyl oxime as a key building block. In particular, we describe a multistep continuous synthesis of this intermediate and demonstrate the advantages of our set-up upon scaling up.
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Identifiers
External DOI: https://doi.org/10.1021/acs/oprd.8b00095
This record's URL: https://www.repository.cam.ac.uk/handle/1810/279948
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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