A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles

Ley, SV; Godineau, Edouard; Battilocchio, Claudio; Lehmann, Matthias; Labes, Ricardo; Birnoschi, letitia; Subramanian, Srinivas; Prasanna, CS; Gorde, Amol; Kalbagh, Mahesh; Khade, Vivek; Scherrer, Anton; O'Sullivan, Anthony Cornelius

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Authors

Ley, SV

Godineau, Edouard

Battilocchio, Claudio

Lehmann, Matthias

Labes, Ricardo

Birnoschi, letitia

Subramanian, Srinivas

Journal Title

OPRD

Type

Article

Metadata

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Citation

Ley, S., Godineau, E., Battilocchio, C., Lehmann, M., Labes, R., Birnoschi, l., Subramanian, S., et al. (2018). A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles. OPRD https://doi.org/10.1021/acs/oprd.8b00095

Abstract

We report a strategy designed for the rapid and convergent assembly of C4-oxime substituted thiazoles. Our approach relied on 3-bromo-2-oxopropanal O-methyl oxime as a key building block. In particular, we describe a multistep continuous synthesis of this intermediate and demonstrate the advantages of our set-up upon scaling up.

Sponsorship

Engineering and Physical Sciences Research Council (EP/K009494/1)

Engineering and Physical Sciences Research Council (EP/M004120/1)

Identifiers

External DOI: https://doi.org/10.1021/acs/oprd.8b00095

This record's URL: https://www.repository.cam.ac.uk/handle/1810/279948

Rights

Licence:

http://creativecommons.org/licenses/by/4.0/

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