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A Continuous Multistep Process for the Preparation of 3-Bromo-2-Oxopropanal O-methyl Oxime as a Precursor to Access C4-Oxime-Substituted Thiazoles

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Ley, SV 
Godineau, Edouard 
Battilocchio, Claudio 
Lehmann, Matthias 

Abstract

We report a strategy designed for the rapid and convergent assembly of C4-oxime substituted thiazoles. Our approach relied on 3-bromo-2-oxopropanal O-methyl oxime as a key building block. In particular, we describe a multistep continuous synthesis of this intermediate and demonstrate the advantages of our set-up upon scaling up.

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Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)