An early history of T cell-mediated cytotoxicity.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Golstein, Pierre https://orcid.org/0000-0003-1750-3483
Griffiths, Gillian M
Abstract
After 60 years of intense fundamental research into T cell-mediated cytotoxicity, we have gained a detailed knowledge of the cells involved, specific recognition mechanisms and post-recognition perforin-granzyme-based and FAS-based molecular mechanisms. What could not be anticipated at the outset was how discovery of the mechanisms regulating the activation and function of cytotoxic T cells would lead to new developments in cancer immunotherapy. Given the profound recent interest in therapeutic manipulation of cytotoxic T cell responses, it is an opportune time to look back on the early history of the field. This Timeline describes how the early findings occurred and eventually led to current therapeutic applications.
Description
Keywords
Animals, Cytotoxicity, Immunologic, Fas Ligand Protein, Granzymes, History, 20th Century, History, 21st Century, Humans, Immunity, Cellular, Immunotherapy, Isoantigens, Models, Immunological, Perforin, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes, Cytotoxic, fas Receptor
Journal Title
Nat Rev Immunol
Conference Name
Journal ISSN
1474-1733
1474-1741
1474-1741
Volume Title
18
Publisher
Springer Science and Business Media LLC
Publisher DOI
Sponsorship
Wellcome Trust (100140/Z/12/Z)
Wellcome Trust (103930/Z/14/Z)
Wellcome Trust (103930/Z/14/Z)