Translational control during developmental transitions
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Publication Date
2019-06-03Journal Title
Cold Spring Harbor perspectives in biology
ISSN
1943-0264
Publisher
Cold Spring Harbor Laboratory Press
Volume
10
Issue
9
Language
eng
Type
Article
This Version
AM
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Karam Teixeira, F., & Lehmann, R. (2019). Translational control during developmental transitions. Cold Spring Harbor perspectives in biology, 10 (9) https://doi.org/10.1101/cshperspect.a032987
Abstract
The many steps of gene expression, from the transcription of a gene to the production of its protein product, are well understood. Yet, transcriptional regulation has been the focal point for the study of gene expression during development. However, quantitative studies reveal that mRNA levels are not necessarily good predictors of the respective proteins’ levels in a cell. This discrepancy is, at least in part, due to developmentally regulated, translational mechanisms that control the spatiotemporal regulation of gene expression. In this review, we focus on translational regulatory mechanisms mediating global transitions in gene expression: the shift from the maternal to the embryonic developmental program in the early embryo and the switch from the self-renewal of stem cells to differentiation in the adult.
Sponsorship
Wellcome Trust (206257/Z/17/Z)
Identifiers
External DOI: https://doi.org/10.1101/cshperspect.a032987
This record's URL: https://www.repository.cam.ac.uk/handle/1810/280375
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http://www.rioxx.net/licenses/all-rights-reserved
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