Graphitic and oxidised high pressure high temperature (HPHT) nanodiamonds induce differential biological responses in breast cancer cell lines.
Royal Society of Chemistry (RSC)
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Woodhams, B., Ansel-Bollepalli, L., Surmacki, J., Knowles, H., Maggini, L., De Volder, M., Atatüre, M., & et al. (2018). Graphitic and oxidised high pressure high temperature (HPHT) nanodiamonds induce differential biological responses in breast cancer cell lines.. Nanoscale, 10 (25), 12169-12179. https://doi.org/10.1039/c8nr02177e
Nanodiamonds have demonstrated potential as powerful sensors in biomedicine, however, their translation into routine use requires a comprehensive understanding of their effect on the biological system being interrogated. Under normal fabrication processes, nanodiamonds are produced with a graphitic carbon shell, but are often oxidized in order to modify their surface chemistry for targeting to specific cellular compartments. Here, we assessed the biological impact of this purification process, considering cellular proliferation, uptake, and oxidative stress for graphitic and oxidized nanodiamond surfaces. We show for the first time that oxidized nanodiamonds possess improved biocompatibility compared to graphitic nanodiamonds in breast cancer cell lines, with graphitic nanodiamonds inducing higher levels of oxidative stress despite lower uptake.
Cell Line, Tumor, Humans, Breast Neoplasms, Graphite, Cell Proliferation, Oxidative Stress, Hot Temperature, Nanodiamonds
European Commission (630729)
Cancer Research UK (16267)
Cancer Research UK (C14303/A17197)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (702435)
External DOI: https://doi.org/10.1039/c8nr02177e
This record's URL: https://www.repository.cam.ac.uk/handle/1810/280751
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/