Graphitic and oxidised high pressure high temperature (HPHT) nanodiamonds induce differential biological responses in breast cancer cell lines.
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Authors
Ansel-Bollepalli, Laura
Publication Date
2018-07Journal Title
Nanoscale
ISSN
2040-3364
Publisher
Royal Society of Chemistry (RSC)
Volume
10
Issue
25
Pages
12169-12179
Language
eng
Type
Article
Physical Medium
Print
Metadata
Show full item recordCitation
Woodhams, B., Ansel-Bollepalli, L., Surmacki, J., Knowles, H., Maggini, L., De Volder, M., Atatüre, M., & et al. (2018). Graphitic and oxidised high pressure high temperature (HPHT) nanodiamonds induce differential biological responses in breast cancer cell lines.. Nanoscale, 10 (25), 12169-12179. https://doi.org/10.1039/c8nr02177e
Abstract
Nanodiamonds have demonstrated potential as powerful sensors in biomedicine, however, their translation into routine use requires a comprehensive understanding of their effect on the biological system being interrogated. Under normal fabrication processes, nanodiamonds are produced with a graphitic carbon shell, but are often oxidized in order to modify their surface chemistry for targeting to specific cellular compartments. Here, we assessed the biological impact of this purification process, considering cellular proliferation, uptake, and oxidative stress for graphitic and oxidized nanodiamond surfaces. We show for the first time that oxidized nanodiamonds possess improved biocompatibility compared to graphitic nanodiamonds in breast cancer cell lines, with graphitic nanodiamonds inducing higher levels of oxidative stress despite lower uptake.
Keywords
Cell Line, Tumor, Humans, Breast Neoplasms, Graphite, Cell Proliferation, Oxidative Stress, Hot Temperature, Nanodiamonds
Sponsorship
European Commission (630729)
Cancer Research UK (16267)
Cancer Research UK (C14303_do not transfer)
EPSRC (EP/N014588/1)
EPSRC (EP/G037221/1)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (702435)
Identifiers
External DOI: https://doi.org/10.1039/c8nr02177e
This record's URL: https://www.repository.cam.ac.uk/handle/1810/280751