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dc.contributor.authorTarp, Jakoben
dc.contributor.authorChild, Abbeyen
dc.contributor.authorWhite, Thomasen
dc.contributor.authorWestgate, Kateen
dc.contributor.authorBugge, Annaen
dc.contributor.authorGrøntved, Andersen
dc.contributor.authorWedderkopp, Nielsen
dc.contributor.authorAndersen, Lars Ben
dc.contributor.authorCardon, Greeten
dc.contributor.authorDavey, Rachelen
dc.contributor.authorJanz, Kathleen Fen
dc.contributor.authorKriemler, Susien
dc.contributor.authorNorthstone, Kateen
dc.contributor.authorPage, Angie Sen
dc.contributor.authorPuder, Jardena Jen
dc.contributor.authorReilly, John Jen
dc.contributor.authorSardinha, Luis Ben
dc.contributor.authorSardinha, Luis Ben
dc.contributor.authorVan Sluijs, Estheren
dc.contributor.authorEkelund, Ulfen
dc.contributor.authorWijndaele, Katrienen
dc.contributor.authorBrage, Sorenen
dc.contributor.authorInternational Children’s Accelerometry Database (ICAD) Collaborators,en
dc.date.accessioned2018-09-27T14:10:07Z
dc.date.available2018-09-27T14:10:07Z
dc.date.issued2018-09en
dc.identifier.issn0307-0565
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/282795
dc.description.abstractAbstract Objectives: To determine the role of physical activity intensity and bout-duration in modulating associations between physical activity and cardiometabolic risk markers. Methods: A cross-sectional study using the International Children’s Accelerometry Database (ICAD) including 38 306 observations (in 29 734 individuals aged 4 – 18 years). Accelerometry data was summarized as time accumulated in 16 combinations of intensity thresholds (≥500 to ≥3000 counts/minute) and bout-durations (≥1 to ≥10 minutes). Outcomes were body mass index (BMI, kg/m2), waist circumference, biochemical markers, blood pressure, and a composite score of these metabolic markers. A second composite score excluded the adiposity component. Linear mixed models were applied to elucidate the associations and expressed per 10 minutes difference in daily activity above the intensity/bout-duration combination. Estimates (and variance) from each of the 16 combinations of intensity and bout-duration examined in the linear mixed models were analysed in meta-regression to investigate trends in the association. Results: Each 10 minute positive difference in physical activity was significantly and inversely associated with the risk factors irrespective of the combination of intensity and bout-duration. In meta-regression, each 1000 counts/min increase in intensity threshold was associated with a -0.027 (95% CI: -0.039 to -0.014) standard deviations lower composite risk score, and a -0.064 (95% CI: -0.09 to -0.038) kg/m2 lower BMI. Conversely, meta-regression suggested bout-duration was not significantly associated with effect-sizes (per 1 minute increase in bout-duration: -0.002 (95% CI: -0.005 to 0.0005) standard deviations for the composite risk score, and -0.005 (95% CI: -0.012 to 0.002) kg/m2 for BMI). Conclusions: Time spent at higher intensity physical activity was the main determinant of variation in cardiometabolic risk factors, not bout-duration. Greater magnitude of associations was consistently observed with higher intensities. These results suggest that, in children and adolescents, physical activity, preferably at higher intensities, of any bout-duration should be promoted.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherSpringer Nature
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectInternational Children’s Accelerometry Database (ICAD) Collaboratorsen
dc.subjectHumansen
dc.subjectCardiovascular Diseasesen
dc.subjectObesityen
dc.subjectInsulinen
dc.subjectBlood Glucoseen
dc.subjectBody Mass Indexen
dc.subjectExerciseen
dc.subjectRisk Factorsen
dc.subjectCross-Sectional Studiesen
dc.subjectBlood Pressureen
dc.subjectAdolescenten
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectWaist Circumferenceen
dc.subjectPhysical Conditioning, Humanen
dc.subjectBiomarkersen
dc.titlePhysical activity intensity, bout-duration, and cardiometabolic risk markers in children and adolescents.en
dc.typeArticle
prism.endingPage1650
prism.issueIdentifier9en
prism.publicationDate2018en
prism.publicationNameInternational journal of obesity (2005)en
prism.startingPage1639
prism.volume42en
dc.identifier.doi10.17863/CAM.30159
dcterms.dateAccepted2018-06-03en
rioxxterms.versionofrecord10.1038/s41366-018-0152-8en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-09en
dc.contributor.orcidTarp, Jakob [0000-0002-9186-7077]
dc.contributor.orcidWhite, Thomas [0000-0001-8456-0803]
dc.contributor.orcidWestgate, Kate [0000-0002-0283-3562]
dc.contributor.orcidBugge, Anna [0000-0002-8345-1434]
dc.contributor.orcidGrøntved, Anders [0000-0003-1584-679X]
dc.contributor.orcidWedderkopp, Niels [0000-0002-9660-6618]
dc.contributor.orcidNorthstone, Kate [0000-0002-0602-1983]
dc.contributor.orcidSardinha, Luis B [0000-0002-6230-6027]
dc.contributor.orcidSardinha, Luis B [0000-0002-0519-6204]
dc.contributor.orcidvan Sluijs, Esther [0000-0001-9141-9082]
dc.contributor.orcidEkelund, Ulf [0000-0003-2115-9267]
dc.contributor.orcidWijndaele, Katrien [0000-0003-2199-7981]
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.identifier.eissn1476-5497
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/3)
pubs.funder-project-idMRC (MC_UU_12015/7)
pubs.funder-project-idWellcome Trust (087636/Z/08/Z)
pubs.funder-project-idESRC (ES/G007462/1)
pubs.funder-project-idMRC (MR/K023187/1)
pubs.funder-project-idBritish Heart Foundation (FS/12/58/29709)
pubs.funder-project-idMedical Research Council (G0701877)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International