MUC16 Mutations and Prognosis in Gastric Cancer: A Little Goes a Long Way.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
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Authors
Smyth, Elizabeth C
Fitzgerald, Rebecca C
Abstract
Gastric cancer is a global health problem; although incidence rates are declining, it remains the third most common cause of cancer death worldwide. Patients with advanced disease have limited treatment options, and most will live for less than 2 years. Therefore, exploration of gastric cancer disease biology is warranted to identify new targets for treatment. Recent comprehensive molecular analyses have identified distinct subgroups of gastric cancer that may have therapeutic relevance. With the exception of microsatellite-unstable tumors, however, the potential for genomically guided therapy has not been realized.
Description
Keywords
CA-125 Antigen, Humans, Membrane Proteins, Mutation, Neoplasms, Prognosis
Journal Title
JAMA Oncol
Conference Name
Journal ISSN
2374-2437
2374-2445
2374-2445
Volume Title
4
Publisher
American Medical Association (AMA)
Publisher DOI
Sponsorship
MRC (unknown)
Medical Research Council (MC_UU_12022/2)
Medical Research Council (MC_UU_12022/2)