MUC16 Mutations and Prognosis in Gastric Cancer: A Little Goes a Long Way.

Authors
Smyth, Elizabeth C 
Fitzgerald, Rebecca C 

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Type
Article
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Abstract

Gastric cancer is a global health problem; although incidence rates are declining, it remains the third most common cause of cancer death worldwide. Patients with advanced disease have limited treatment options, and most will live for less than 2 years. Therefore, exploration of gastric cancer disease biology is warranted to identify new targets for treatment. Recent comprehensive molecular analyses have identified distinct subgroups of gastric cancer that may have therapeutic relevance. With the exception of microsatellite-unstable tumors, however, the potential for genomically guided therapy has not been realized.

Publication Date
2018-12-01
Online Publication Date
2018-08-09
Acceptance Date
2018-06-19
Keywords
CA-125 Antigen, Humans, Membrane Proteins, Mutation, Neoplasms, Prognosis
Journal Title
JAMA Oncol
Journal ISSN
2374-2437
2374-2445
Volume Title
4
Publisher
American Medical Association (AMA)
Sponsorship
MRC (unknown)
Medical Research Council (MC_UU_12022/2)