MUC16 Mutations and Prognosis in Gastric Cancer: A Little Goes a Long Way.
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Authors
Smyth, Elizabeth C
Fitzgerald, Rebecca C
Publication Date
2018-12-01Journal Title
JAMA Oncol
ISSN
2374-2437
Publisher
American Medical Association (AMA)
Volume
4
Issue
12
Pages
1698-1699
Language
eng
Type
Article
Physical Medium
Print
Metadata
Show full item recordCitation
Smyth, E. C., & Fitzgerald, R. C. (2018). MUC16 Mutations and Prognosis in Gastric Cancer: A Little Goes a Long Way.. JAMA Oncol, 4 (12), 1698-1699. https://doi.org/10.1001/jamaoncol.2018.2803
Abstract
Gastric cancer is a global health problem; although incidence rates are declining, it remains the third most common cause of cancer death worldwide. Patients with advanced disease have limited treatment options, and most will live for less than 2 years. Therefore, exploration of gastric cancer disease biology is warranted to identify new targets for treatment. Recent comprehensive molecular analyses have identified distinct subgroups of gastric cancer that may have therapeutic relevance. With the exception of microsatellite-unstable tumors, however, the potential for genomically guided therapy has not been realized.
Keywords
Humans, Neoplasms, Membrane Proteins, CA-125 Antigen, Prognosis, Mutation
Sponsorship
MRC (unknown)
Medical Research Council (MC_UU_12022/2)
Identifiers
External DOI: https://doi.org/10.1001/jamaoncol.2018.2803
This record's URL: https://www.repository.cam.ac.uk/handle/1810/282847
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http://www.rioxx.net/licenses/all-rights-reserved
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