From pulsatile apicomedial contractility to effective epithelial mechanics.

Authors
Blanchard, Guy B 
Étienne, Jocelyn 
Gorfinkiel, Nicole 

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Type
Article
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Abstract

We review recent developments in the understanding of the biomechanics of apicomedial actomyosin and how its contractility can tense and deform tissue. Myosin pulses are driven by a biochemical oscillator but how they are modulated by the mechanical context remains unclear. On the other hand, the emergence of tissue behaviour is highly dependent on the material properties of actin, on how strongly components are connected and on the influence of neighbouring tissues. We further review the use of constitutive equations in exploring the mechanics of epithelial apices dominated by apicomedial Myosin contractility.

Publication Date
2018-08
Online Publication Date
2018-08
Acceptance Date
2018-07-16
Keywords
Actins, Actomyosin, Biomechanical Phenomena, Epithelium, Humans, Myosins
Journal Title
Curr Opin Genet Dev
Journal ISSN
0959-437X
1879-0380
Volume Title
51
Publisher
Elsevier BV
Sponsorship
Wellcome Trust (099234/Z/12/Z)
Biotechnology and Biological Sciences Research Council (BB/J010278/1)