In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients.
Wright, Adam KA
Simmonds, Rosalind P
Solanki, Chandra K
Peters, A Michael
Condliffe, Alison M
The Journal of allergy and clinical immunology
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Farahi, N., Loutsios, C., Tregay, N., Wright, A. K., Berair, R., Lok, L., Gillett, D., et al. (2018). In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients.. The Journal of allergy and clinical immunology, 142 (5), 1659-1662.e8. https://doi.org/10.1016/j.jaci.2018.07.011
To The Editor: Eosinophils play an important pathogenic role in pulmonary and systemic conditions including eosinophilic asthma and eosinophilic granulomatosis with polyangiitis.1,2 While progress has been made in understanding the mechanisms responsible for the activation of these cells, existing biomarkers of eosinophilic inflammation are indirect and/or invasive and do not always correlate with tissue eosinophilia. Hence, there is a need to develop non-invasive biomarkers of tissue eosinophilia. We have previously demonstrated the capacity of SPECT (single photon emission computed tomography) to quantify neutrophil uptake into the lungs of COPD patients.3 We sought to determine whether this methodology could be used to quantify eosinophil kinetics and pulmonary uptake, which may differ amongst diseases characterized by eosinophilic inflammation. In particular, the role of the eosinophil in asthma with obesity, a distinct asthma endotype associated with increased severity,4 is controversial. We hypothesized that injection of radiolabeled eosinophils, coupled with SPECT/CT, would reveal changes in eosinophil kinetics in patients compared to healthy volunteers.
Lung, Eosinophils, Humans, Asthma, Eosinophilia, Obesity, Aged, Middle Aged, Female, Male, Single Photon Emission Computed Tomography Computed Tomography
This work was supported by Asthma UK [08/11], the Medical Research Council [grant number MR/J00345X/1], the Wellcome Trust [grant number 098351/Z/12/Z], Cambridge NIHR Biomedical Research Centre, Wellcome Trust Senior Fellowship (to CEB) [grant number WT082265], AirPROM 7th EU Framework grant and Leicester NIHR Biomedical Research Centre.
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
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External DOI: https://doi.org/10.1016/j.jaci.2018.07.011
This record's URL: https://www.repository.cam.ac.uk/handle/1810/283632
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
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