The Role of aDNA in Understanding the Coevolutionary Patterns of Human Sexually Transmitted Infections.
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Pimenoff, V. N., Houldcroft, C., Rifkin, R. F., & Underdown, S. (2018). The Role of aDNA in Understanding the Coevolutionary Patterns of Human Sexually Transmitted Infections.. Genes (Basel), 9 (7) https://doi.org/10.3390/genes9070317
Analysis of pathogen genome data sequenced from clinical and historical samples has made it possible to perform phylogenetic analyses of sexually transmitted infections on a global scale, and to estimate the diversity, distribution, and coevolutionary host relationships of these pathogens, providing insights into pathogen emergence and disease prevention. Deep-sequenced pathogen genomes from clinical studies and ancient samples yield estimates of within-host and between-host evolutionary rates and provide data on changes in pathogen genomic stability and evolutionary responses. Here we examine three groups of pathogens transmitted mainly through sexual contact between modern humans to provide insight into ancient human behavior and history with their pathogens. Exploring ancient pathogen genomic divergence and the ancient viral-host parallel evolutionary histories will help us to reconstruct the origin of present-day geographical distribution and diversity of clinical pathogen infections, and will hopefully allow us to foresee possible environmentally induced pathogen evolutionary responses. Lastly, we emphasize that ancient pathogen DNA research should be combined with modern clinical pathogen data, and be equitable and provide advantages for all researchers worldwide, e.g., through shared data.
NIHR Cambridge Biomedical Research Centre Anti-Microbial Resistance theme
Cambridge University Hospitals NHS Foundation Trust (CUH) (BRC)
External DOI: https://doi.org/10.3390/genes9070317
This record's URL: https://www.repository.cam.ac.uk/handle/1810/284122
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/