Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Popova, Semiramis A https://orcid.org/0000-0002-3200-4247
Buczacki, Simon JA https://orcid.org/0000-0002-2975-416X
Abstract
Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through non-canonical hedgehog signalling effects on the WNT pathway.
Description
Keywords
cancer stem cell, cell cycle, colorectal cancer, dormancy, hedgehog, heterogeneity, itraconazole, plasticity, wnt
Journal Title
Mol Cell Oncol
Conference Name
Journal ISSN
2372-3556
2372-3556
2372-3556
Volume Title
5
Publisher
Informa UK Limited
Publisher DOI
Sponsorship
Cancer Research Uk (None)