Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition.
Mol Cell Oncol
Informa UK Limited
MetadataShow full item record
Popova, S. A., & Buczacki, S. J. (2018). Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition.. Mol Cell Oncol, 5 (4), e1494950. https://doi.org/10.1080/23723556.2018.1494950
Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through non-canonical hedgehog signalling effects on the WNT pathway.
cancer stem cell, cell cycle, colorectal cancer, dormancy, hedgehog, heterogeneity, itraconazole, plasticity, wnt
Cancer Research Uk (None)
External DOI: https://doi.org/10.1080/23723556.2018.1494950
This record's URL: https://www.repository.cam.ac.uk/handle/1810/284123
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
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