Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition.

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Authors
  Popova, Semiramis A
  Buczacki, Simon JA
Publication Date
2018
Journal Title
Mol Cell Oncol
ISSN
2372-3556
Publisher
Informa UK Limited
Volume
5
Issue
4
Pages
e1494950
Language
eng
Type
Article
Physical Medium
Electronic-eCollection
Metadata
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Citation
Popova, S. A., & Buczacki, S. J. (2018). Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition.. Mol Cell Oncol, 5 (4), e1494950. https://doi.org/10.1080/23723556.2018.1494950
Abstract
Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through non-canonical hedgehog signalling effects on the WNT pathway.
Keywords
cancer stem cell, cell cycle, colorectal cancer, dormancy, hedgehog, heterogeneity, itraconazole, plasticity, wnt
Sponsorship
Cancer Research Uk (None)
Identifiers
External DOI: https://doi.org/10.1080/23723556.2018.1494950
This record's URL: https://www.repository.cam.ac.uk/handle/1810/284123
Rights
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International