Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition.

Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition.

Published version

Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/284123

Repository DOI

https://doi.org/10.17863/CAM.31494

Files

Published version (945.56 KB)

Type

Authors

Popova, Semiramis A

https://orcid.org/0000-0002-3200-4247

Buczacki, Simon JA

https://orcid.org/0000-0002-2975-416X

Abstract

Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through non-canonical hedgehog signalling effects on the WNT pathway.

Keywords

cancer stem cell, cell cycle, colorectal cancer, dormancy, hedgehog, heterogeneity, itraconazole, plasticity, wnt

Journal Title

Mol Cell Oncol

Journal ISSN

2372-3556
2372-3556

Volume Title

5

Publisher

Taylor & Francis

Publisher DOI

https://doi.org/10.1080/23723556.2018.1494950

Rights and licensing

Attribution 4.0 International

Except where otherwised noted, this item's license is described as Attribution 4.0 International

Sponsorship

Cancer Research Uk (None)

Collections

University of Cambridge Research Outputs (Articles and Conferences)