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Different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation.

Accepted version
Peer-reviewed

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Abstract

Paredes et al recently described Poldip2 as a novel regulator of mitochondrial lipoylation through stabilisation of ACSM1 (1). We have several concerns with their proposed model based on the following reasons.

Description

Journal Title

Proc Natl Acad Sci U S A

Conference Name

Journal ISSN

0027-8424
1091-6490

Volume Title

115

Publisher

Proceedings of the National Academy of Sciences

Rights and licensing

Except where otherwised noted, this item's license is described as All rights reserved
Sponsorship
Wellcome Trust (102770/Z/13/Z)
Lister Institute of Preventive Medicine (unknown)
Wellcome Trust (205252/Z/16/Z)
Wellcome 102770/Z/13/Z and 205252/Z/16/Z Lister Institute RG87950