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Different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Bailey, Peter SJ 
Hiltunen, J Kalervo  ORCID logo  https://orcid.org/0000-0002-3073-9602
Dieckmann, Carol L 
Kastaniotis, Alexander J  ORCID logo  https://orcid.org/0000-0003-3624-9214

Abstract

Paredes et al recently described Poldip2 as a novel regulator of mitochondrial lipoylation through stabilisation of ACSM1 (1). We have several concerns with their proposed model based on the following reasons.

Description

Keywords

Animals, Attitude, Hypoxia-Inducible Factor 1, Thioctic Acid

Journal Title

Proc Natl Acad Sci U S A

Conference Name

Journal ISSN

0027-8424
1091-6490

Volume Title

115

Publisher

Proceedings of the National Academy of Sciences
Sponsorship
Wellcome Trust (102770/Z/13/Z)
Lister Institute of Preventive Medicine (unknown)
Wellcome Trust (205252/Z/16/Z)
Wellcome 102770/Z/13/Z and 205252/Z/16/Z Lister Institute RG87950