Different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Bailey, Peter SJ
Hiltunen, J Kalervo https://orcid.org/0000-0002-3073-9602
Dieckmann, Carol L
Kastaniotis, Alexander J https://orcid.org/0000-0003-3624-9214
Nathan, James A https://orcid.org/0000-0002-0248-1632
Abstract
Paredes et al recently described Poldip2 as a novel regulator of mitochondrial lipoylation through stabilisation of ACSM1 (1). We have several concerns with their proposed model based on the following reasons.
Description
Keywords
Animals, Attitude, Hypoxia-Inducible Factor 1, Thioctic Acid
Journal Title
Proc Natl Acad Sci U S A
Conference Name
Journal ISSN
0027-8424
1091-6490
1091-6490
Volume Title
115
Publisher
Proceedings of the National Academy of Sciences
Publisher DOI
Sponsorship
Wellcome Trust (102770/Z/13/Z)
Lister Institute of Preventive Medicine (unknown)
Wellcome Trust (205252/Z/16/Z)
Lister Institute of Preventive Medicine (unknown)
Wellcome Trust (205252/Z/16/Z)
Wellcome 102770/Z/13/Z and 205252/Z/16/Z
Lister Institute RG87950