Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.
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Publication Date
2016-07-15Journal Title
Cardiovasc Res
ISSN
0008-6363
Publisher
Oxford University Press (OUP)
Volume
111
Issue
2
Pages
134-141
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Pell, V. R., Chouchani, E. T., Frezza, C., Murphy, M. P., & Krieg, T. (2016). Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.. Cardiovasc Res, 111 (2), 134-141. https://doi.org/10.1093/cvr/cvw100
Abstract
Myocardial ischaemia/reperfusion (IR) injury is a major cause of death worldwide and remains a disease for which current clinical therapies are strikingly deficient. While the production of mitochondrial reactive oxygen species (ROS) is a critical driver of tissue damage upon reperfusion, the precise mechanisms underlying ROS production have remained elusive. More recently, it has been demonstrated that a specific metabolic mechanism occurs during ischaemia that underlies elevated ROS at reperfusion, suggesting a unifying model as to why so many different compounds have been found to be cardioprotective against IR injury. This review will discuss the role of the citric acid cycle intermediate succinate in IR pathology focusing on the mechanism by which this metabolite accumulates during ischaemia and how it can drive ROS production at Complex I via reverse electron transport. We will then examine the potential for manipulating succinate accumulation and metabolism during IR injury in order to protect the heart against IR damage and discuss targets for novel therapeutics designed to reduce reperfusion injury in patients.
Keywords
Ischaemia/reperfusion, Mitochondria, Reactive oxygen species, Succinate, Animals, Cardiovascular Agents, Electron Transport, Electron Transport Complex I, Electron Transport Complex II, Energy Metabolism, Humans, Myocardial Reperfusion Injury, Myocardium, Reactive Oxygen Species, Signal Transduction, Succinic Acid
Sponsorship
Medical Research Council (MC_UU_12022/6)
Medical Research Council (MC_U105663142)
Identifiers
External DOI: https://doi.org/10.1093/cvr/cvw100
This record's URL: https://www.repository.cam.ac.uk/handle/1810/284972
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http://www.rioxx.net/licenses/all-rights-reserved
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