IL-33 (Interleukin 33)/sST2 Axis in Hypertension and Heart Failure.
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Authors
Ghali, Rana
Altara, Raffaele
Louch, William E
Cataliotti, Alessandro
Kaplan, Abdullah
Zouein, Fouad A
Booz, George W
Publication Date
2018-10Journal Title
Hypertension
ISSN
0194-911X
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
72
Issue
4
Pages
818-828
Language
eng
Type
Article
Physical Medium
Print
Metadata
Show full item recordCitation
Ghali, R., Altara, R., Louch, W. E., Cataliotti, A., Mallat, Z., Kaplan, A., Zouein, F. A., & et al. (2018). IL-33 (Interleukin 33)/sST2 Axis in Hypertension and Heart Failure.. Hypertension, 72 (4), 818-828. https://doi.org/10.1161/HYPERTENSIONAHA.118.11157
Abstract
IL-33 (interleukin 33) is type of cytokine designated an alarmin, which is released under stress conditions or by cell death to induce protective measures in neighboring cells.1 It signals via the ST2 (suppression of tumorigenicity 2) receptor, which is also expressed as a truncated and soluble form that acts as a decoy receptor soluble ST2 (sST2).2 Substantial evidence supports the use of sST2 measurement as an indicator of cardiac stress and remodeling in hypertension, heart failure, cardiomyopathies, and aortic stenosis (AS). However, as discussed here, there are gaps in our understanding of the IL-33/sST2 axis, including the source of the components, stimuli for their expression and release, what it actually assesses, and the role of immune cells. Moreover, as discussed, the fundamental assumption that Il-33 has beneficial actions that are thwarted by sST2 requires further scrutiny.
Keywords
Humans, Hypertension, Signal Transduction, Heart Failure, Biomarkers, Interleukin-33, Interleukin-1 Receptor-Like 1 Protein
Sponsorship
British Heart Foundation (CH/10/001/27642)
British Heart Foundation (PG/15/99/31865)
Identifiers
External DOI: https://doi.org/10.1161/HYPERTENSIONAHA.118.11157
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285627
Rights
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http://www.rioxx.net/licenses/all-rights-reserved
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