Electrophoretic drug delivery for seizure control.
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Authors
Slézia, Andrea
Williamson, Adam
Publication Date
2018-08Journal Title
Sci Adv
ISSN
2375-2548
Publisher
American Association for the Advancement of Science (AAAS)
Volume
4
Issue
8
Pages
eaau1291
Language
eng
Type
Article
Physical Medium
Electronic-eCollection
Metadata
Show full item recordCitation
Proctor, C. M., Slézia, A., Kaszas, A., Ghestem, A., Del Agua, I., Pappa, A., Bernard, C., et al. (2018). Electrophoretic drug delivery for seizure control.. Sci Adv, 4 (8), eaau1291. https://doi.org/10.1126/sciadv.aau1291
Abstract
The persistence of intractable neurological disorders necessitates novel therapeutic solutions. We demonstrate the utility of direct in situ electrophoretic drug delivery to treat neurological disorders. We present a neural probe incorporating a microfluidic ion pump (μFIP) for on-demand drug delivery and electrodes for recording local neural activity. The μFIP works by electrophoretically pumping ions across an ion exchange membrane and thereby delivers only the drug of interest and not the solvent. This "dry" delivery enables precise drug release into the brain region with negligible local pressure increase. The therapeutic potential of the μFIP probe is tested in a rodent model of epilepsy. The μFIP probe can detect pathological activity and then intervene to stop seizures by delivering inhibitory neurotransmitters directly to the seizure source. We anticipate that further tailored engineering of the μFIP platform will enable additional applications in neural interfacing and the treatment of neurological disorders.
Keywords
Animals, Mice, Seizures, gamma-Aminobutyric Acid, GABA Agents, Drug Delivery Systems, Microfluidics
Identifiers
External DOI: https://doi.org/10.1126/sciadv.aau1291
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285800
Rights
Attribution-NonCommercial 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc/4.0/
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