The dynamic mechanical properties of cellularised aggregates.
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Publication Date
2016-10Journal Title
Curr Opin Cell Biol
ISSN
0955-0674
Publisher
Elsevier BV
Volume
42
Pages
113-120
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Khalilgharibi, N., Fouchard, J., Recho, P., Charras, G., & Kabla, A. (2016). The dynamic mechanical properties of cellularised aggregates.. Curr Opin Cell Biol, 42 113-120. https://doi.org/10.1016/j.ceb.2016.06.003
Abstract
Cellularised materials are composed of cells interfaced through specialised intercellular junctions that link the cytoskeleton of one cell to that of its neighbours allowing for transmission of forces. Cellularised materials are common in early development and adult tissues where they can be found in the form of cell sheets, cysts, or amorphous aggregates and in pathophysiological conditions such as cancerous tumours. Given the growing realisation that forces can regulate cell physiology and developmental processes, understanding how cellularised materials deform under mechanical stress or dissipate stress appear as key biological questions. In this review, we will discuss the dynamic mechanical properties of cellularised materials devoid of extracellular matrix.
Keywords
Cells, Animals, Humans, Rheology, Cell Aggregation, Morphogenesis, Models, Biological, Biomechanical Phenomena
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/M002578/1)
Identifiers
External DOI: https://doi.org/10.1016/j.ceb.2016.06.003
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285932
Rights
Licence:
http://www.rioxx.net/licenses/all-rights-reserved
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