Repository logo
 

The dynamic mechanical properties of cellularised aggregates.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Khalilgharibi, Nargess 
Fouchard, Jonathan 
Recho, Pierre 
Charras, Guillaume 

Abstract

Cellularised materials are composed of cells interfaced through specialised intercellular junctions that link the cytoskeleton of one cell to that of its neighbours allowing for transmission of forces. Cellularised materials are common in early development and adult tissues where they can be found in the form of cell sheets, cysts, or amorphous aggregates and in pathophysiological conditions such as cancerous tumours. Given the growing realisation that forces can regulate cell physiology and developmental processes, understanding how cellularised materials deform under mechanical stress or dissipate stress appear as key biological questions. In this review, we will discuss the dynamic mechanical properties of cellularised materials devoid of extracellular matrix.

Description

Keywords

Animals, Biomechanical Phenomena, Cell Aggregation, Cells, Humans, Models, Biological, Morphogenesis, Rheology

Journal Title

Curr Opin Cell Biol

Conference Name

Journal ISSN

0955-0674
1879-0410

Volume Title

42

Publisher

Elsevier BV
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/M002578/1)