Advances in understanding nociception and neuropathic pain.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
St John Smith, Ewan https://orcid.org/0000-0002-2699-1979
Abstract
Pain results from the activation of a subset of sensory neurones termed nociceptors and has evolved as a "detect and protect" mechanism. However, lesion or disease in the sensory system can result in neuropathic pain, which serves no protective function. Understanding how the sensory nervous system works and what changes occur in neuropathic pain are vital in identifying new therapeutic targets and developing novel analgesics. In recent years, technologies such as optogenetics and RNA-sequencing have been developed, which alongside the more traditional use of animal neuropathic pain models and insights from genetic variations in humans have enabled significant advances to be made in the mechanistic understanding of neuropathic pain.
Description
Keywords
Chemogenetics, Neurocircuitry, Neuropathic pain, Nociceptor, Optogenetics, Voltage gated sodium channel (NaV), Animals, Humans, Neuralgia, Nociception, Optogenetics, Sensory Receptor Cells, Sequence Analysis, RNA
Journal Title
J Neurol
Conference Name
Journal ISSN
0340-5354
1432-1459
1432-1459
Volume Title
265
Publisher
Springer Science and Business Media LLC
Publisher DOI
Sponsorship
ARTHRITIS RESEARCH UK (20930)
Rosetrees Trust (A1296)
Rosetrees Trust (A1296)