Mapping traumatic axonal injury using diffusion tensor imaging: correlations with functional outcome.
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Authors
Chatfield, Doris
Vowler, Sarah
Manktelow, Anne
Cross, Justin
Scoffings, Daniel
Coleman, Martin
Carpenter, T Adrian
Publication Date
2011-05-04Journal Title
PLoS One
ISSN
1932-6203
Publisher
Public Library of Science (PLoS)
Volume
6
Issue
5
Pages
e19214
Language
eng
Type
Article
Physical Medium
Electronic
Metadata
Show full item recordCitation
Newcombe, V., Chatfield, D., Outtrim, J., Vowler, S., Manktelow, A., Cross, J., Scoffings, D., et al. (2011). Mapping traumatic axonal injury using diffusion tensor imaging: correlations with functional outcome.. PLoS One, 6 (5), e19214. https://doi.org/10.1371/journal.pone.0019214
Abstract
BACKGROUND: Traumatic brain injury is a major cause of morbidity and mortality worldwide. Ameliorating the neurocognitive and physical deficits that accompany traumatic brain injury would be of substantial benefit, but the mechanisms that underlie them are poorly characterized. This study aimed to use diffusion tensor imaging to relate clinical outcome to the burden of white matter injury. METHODOLOGY/PRINCIPAL FINDINGS: Sixty-eight patients, categorized by the Glasgow Outcome Score, underwent magnetic resonance imaging at a median of 11.8 months (range 6.6 months to 3.7 years) years post injury. Control data were obtained from 36 age-matched healthy volunteers. Mean fractional anisotropy, apparent diffusion coefficient (ADC), and eigenvalues were obtained for regions of interest commonly affected in traumatic brain injury. In a subset of patients where conventional magnetic resonance imaging was completely normal, diffusion tensor imaging was able to detect clear abnormalities. Significant trends of increasing ADC with worse outcome were noted in all regions of interest. In the white matter regions of interest worse clinical outcome corresponded with significant trends of decreasing fractional anisotropy. CONCLUSIONS/SIGNIFICANCE: This study found that clinical outcome was related to the burden of white matter injury, quantified by diffusivity parameters late after traumatic brain injury. These differences were seen even in patients with the best outcomes and patients in whom conventional magnetic resonance imaging was normal, suggesting that diffusion tensor imaging can detect subtle injury missed by other techniques. An improved in vivo understanding of the pathology of traumatic brain injury, including its distribution and extent, may enhance outcome evaluation and help to provide a mechanistic basis for deficits that remain unexplained by other approaches.
Keywords
Adolescent, Adult, Aged, Brain Injuries, Case-Control Studies, Diffusion Tensor Imaging, Female, Humans, Male, Middle Aged, Young Adult
Sponsorship
Medical Research Council (G0600986)
Medical Research Council (G9439390)
Medical Research Council (G0001354)
Medical Research Council (G0001237)
Medical Research Council (G1000183)
Identifiers
External DOI: https://doi.org/10.1371/journal.pone.0019214
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286316
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