Prognostic models turn the Heat(IT)up on FLT3ITD-mutated AML.

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Authors
  Gallipoli, Paolo
Huntly, Brian Jp
Publication Date
2019-01-15
Journal Title
Clinical Cancer Research
ISSN
1078-0432
Publisher
American Association for Cancer Research
Language
eng
Type
Article
This Version
AM
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Citation
Gallipoli, P., & Huntly, B. J. (2019). Prognostic models turn the Heat(IT)up on FLT3ITD-mutated AML.. Clinical Cancer Research https://doi.org/10.1158/1078-0432.CCR-18-3146
Abstract
The presence of internal tandem duplications (ITDs) in the FLT3 receptor tyrosine kinase gene have long been known to confer a poor prognosis to acute myeloid leukemia (AML) patients. Now, specific structural features of the ITD are also suggested to alter patient outcome, including sensitivity to targeted therapies, prompting their evaluation in therapeutic algorithms.
Keywords
Hot Temperature, Humans, Leukemia, Myeloid, Acute, Prognosis, Tandem Repeat Sequences, fms-Like Tyrosine Kinase 3
Sponsorship
B.J.P. Huntly is supported by The European Research Council (COMAL: 647685) and Cancer Research UK (A25508). P. Gallipoli is supported by the Wellcome Trust (109967/Z/15/Z) and an ASH Global Research Award.
Funder references
Medical Research Council (MC_PC_12009)
Wellcome Trust (109967/Z/15/Z)
Medical Research Council (MR/M010392/1)
Medical Research Council (MR/R009708/1)
European Research Council (647685)
Identifiers
External DOI: https://doi.org/10.1158/1078-0432.CCR-18-3146
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286784
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Licence:
http://www.rioxx.net/licenses/all-rights-reserved
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