Prognostic models turn the Heat(IT)up on FLT3ITD-mutated AML.
Clinical Cancer Research
American Association for Cancer Research
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Gallipoli, P., & Huntly, B. (2019). Prognostic models turn the Heat(IT)up on FLT3ITD-mutated AML.. Clinical Cancer Research https://doi.org/10.1158/1078-0432.CCR-18-3146
The presence of internal tandem duplications (ITDs) in the FLT3 receptor tyrosine kinase gene have long been known to confer a poor prognosis to acute myeloid leukemia (AML) patients. Now, specific structural features of the ITD are also suggested to alter patient outcome, including sensitivity to targeted therapies, prompting their evaluation in therapeutic algorithms.
B.J.P. Huntly is supported by The European Research Council (COMAL: 647685) and Cancer Research UK (A25508). P. Gallipoli is supported by the Wellcome Trust (109967/Z/15/Z) and an ASH Global Research Award.
Medical Research Council (MC_PC_12009)
Wellcome Trust (109967/Z/15/Z)
Medical Research Council (MR/M010392/1)
Medical Research Council (MR/R009708/1)
European Research Council (647685)
External DOI: https://doi.org/10.1158/1078-0432.CCR-18-3146
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286784