Prognostic models turn the Heat(IT)up on FLT3ITD-mutated AML.
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Peer-reviewed
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Abstract
The presence of internal tandem duplications (ITDs) in the FLT3 receptor tyrosine kinase gene have long been known to confer a poor prognosis to acute myeloid leukemia (AML) patients. Now, specific structural features of the ITD are also suggested to alter patient outcome, including sensitivity to targeted therapies, prompting their evaluation in therapeutic algorithms.
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Clinical Cancer Research
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1078-0432
1557-3265
1557-3265
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American Association for Cancer Research
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Except where otherwised noted, this item's license is described as All rights reserved
Sponsorship
Medical Research Council (MC_PC_12009)
Wellcome Trust (109967/Z/15/Z)
Medical Research Council (MR/M010392/1)
Medical Research Council (MR/R009708/1)
European Research Council (647685)
Cancer Research UK (25508)
Wellcome Trust (109967/Z/15/Z)
Medical Research Council (MR/M010392/1)
Medical Research Council (MR/R009708/1)
European Research Council (647685)
Cancer Research UK (25508)
B.J.P. Huntly is supported by The European Research Council (COMAL: 647685) and Cancer Research UK (A25508). P. Gallipoli is supported by the Wellcome Trust (109967/Z/15/Z) and an ASH Global Research Award.