Models and Tools for Studying Enteroendocrine Cells.
The Endocrine Society
MetadataShow full item record
Goldspink, D., Reimann, F., & Gribble, F. (2018). Models and Tools for Studying Enteroendocrine Cells.. Endocrinology, 159 (12), 3874-3884. https://doi.org/10.1210/en.2018-00672
Gut hormones produced by gastrointestinal enteroendocrine cells modulate key physiological processes including glucose homeostasis and food intake, making them potential therapeutic candidates to treat obesity and diabetes. Understanding the function of enteroendocrine cells and the molecular mechanisms driving hormone production is a key step toward mobilizing endogenous hormone reserves in the gut as a therapeutic strategy. In this review, we will discuss the variety of ex vivo and in vitro model systems driving this research and their contributions to our current understanding of nutrient-sensing mechanisms in enteroendocrine cells.
Gastrointestinal Tract, Animals, Humans, Gastrointestinal Hormones, Endocrinology, Homeostasis, Eating, Models, Biological, Enteroendocrine Cells
Medical Research Council (MC_UU_12012/3)
Wellcome Trust (106262/Z/14/Z)
Medical Research Council (MC_UU_12012/5)
External DOI: https://doi.org/10.1210/en.2018-00672
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286854