Neurochemical and molecular mechanisms underlying the retrieval-extinction effect.
Springer Science and Business Media LLC
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Cahill, E., & Milton, A. (2019). Neurochemical and molecular mechanisms underlying the retrieval-extinction effect.. Psychopharmacology (Berl), 236 (1), 111-132. https://doi.org/10.1007/s00213-018-5121-3
Extinction within the reconsolidation window, or 'retrieval-extinction', has received much research interest as a possible technique for targeting the reconsolidation of maladaptive memories with a behavioural intervention. However, it remains to be determined whether the retrieval-extinction effect-a long-term reduction in fear behaviour, which appears resistant to spontaneous recovery, renewal and reinstatement-depends specifically on destabilisation of the original memory (the 'reconsolidation-update' account) or represents facilitation of an extinction memory (the 'extinction-facilitation' account). We propose that comparing the neurotransmitter systems, receptors and intracellular signalling pathways recruited by reconsolidation, extinction and retrieval-extinction will provide a way of distinguishing between these accounts.
Animals, Humans, Receptors, Dopamine, Receptors, N-Methyl-D-Aspartate, Fear, Conditioning (Psychology), Memory, Extinction, Psychological
Biotechnology and Biological Sciences Research Council (BB/M01407X/1)
Medical Research Council (MR/N02530X/1)
External DOI: https://doi.org/10.1007/s00213-018-5121-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288139
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/