Neurochemical and molecular mechanisms underlying the retrieval-extinction effect.
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Publication Date
2019-01Journal Title
Psychopharmacology (Berl)
ISSN
0033-3158
Publisher
Springer Science and Business Media LLC
Volume
236
Issue
1
Pages
111-132
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Cahill, E. N., & Milton, A. L. (2019). Neurochemical and molecular mechanisms underlying the retrieval-extinction effect.. Psychopharmacology (Berl), 236 (1), 111-132. https://doi.org/10.1007/s00213-018-5121-3
Abstract
Extinction within the reconsolidation window, or 'retrieval-extinction', has received much research interest as a possible technique for targeting the reconsolidation of maladaptive memories with a behavioural intervention. However, it remains to be determined whether the retrieval-extinction effect-a long-term reduction in fear behaviour, which appears resistant to spontaneous recovery, renewal and reinstatement-depends specifically on destabilisation of the original memory (the 'reconsolidation-update' account) or represents facilitation of an extinction memory (the 'extinction-facilitation' account). We propose that comparing the neurotransmitter systems, receptors and intracellular signalling pathways recruited by reconsolidation, extinction and retrieval-extinction will provide a way of distinguishing between these accounts.
Keywords
Animals, Humans, Receptors, Dopamine, Receptors, N-Methyl-D-Aspartate, Fear, Conditioning (Psychology), Memory, Extinction, Psychological
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/M01407X/1)
Medical Research Council (MR/N02530X/1)
Identifiers
External DOI: https://doi.org/10.1007/s00213-018-5121-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288139
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