Short-term gain, long-term pain: the senescence life cycle and cancer.
Cold Spring Harbor Laboratory
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Chan, A. S. L., & Narita, M. (2019). Short-term gain, long-term pain: the senescence life cycle and cancer.. Genes Dev, 33 (3-4), 127-143. https://doi.org/10.1101/gad.320937.118
Originally thought of as a stress response end point, the view of cellular senescence has since evolved into one encompassing a wide range of physiological and pathological functions, including both protumorignic and antitumorigenic features. It has also become evident that senescence is a highly dynamic and heterogenous process. Efforts to reconcile the beneficial and detrimental features of senescence suggest that physiological functions require the transient presence of senescent cells in the tissue microenvironment. Here, we propose the concept of a physiological "senescence life cycle," which has pathological consequences if not executed in its entirety.
Humans, Neoplasms, Precancerous Conditions, Cell Cycle, Epigenomics, Telomere Shortening, Cellular Microenvironment, Cellular Senescence
The Narita laboratory is funded by a Cancer Research UK Cambridge Institute Core Grant (C14303/A17197). Masashi Narita is also supported by Cancer Research UK Early Detection Pump Priming award (C20/A20976), Medical Research Council (MR/R010013/1) and the Tokyo Tech World Research Hub Initiative (WRHI).
Cancer Research UK (CB4210)
Cancer Research UK (C14303/A17197)
Medical Research Council (MR/R010013/1)
Cancer Research UK (C20/A20976)
External DOI: https://doi.org/10.1101/gad.320937.118
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288162