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Circulating Tumor Cells: Come Together, Right Now, Over Metastasis.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Rodrigues, Paulo 

Abstract

Circulating tumor cells (CTC) are the source of metastases, but only an infinitesimal fraction of them eventually succeed in colonizing a distant organ. New results show that CD44-dependent aggregation in the circulation provides CTCs with cancer stem cell-like characteristics, suggesting an explanation for the low metastatic efficiency of CTCs, but also avenues for therapeutic intervention.See related article by Liu et al., p. 96.

Description

Keywords

Breast Neoplasms, Cell Aggregation, Humans, Hyaluronan Receptors, Neoplastic Cells, Circulating, Neoplastic Stem Cells

Journal Title

Cancer Discov

Conference Name

Journal ISSN

2159-8274
2159-8290

Volume Title

9

Publisher

American Association for Cancer Research (AACR)
Sponsorship
Medical Research Council (MC_UU_12022/7)
MRC (unknown)
MRC (MR/N501876/1)
MRC (MR/N501876/1)