The Cellular Environment Affects Monomeric α-Synuclein Structure
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Kaminski, GS
Abstract
Thepresynapticproteina-synuclein(aSyn)isan‘intrinsicallydisorderedprotein’thatishighlydynamicinconformation.TransientintramolecularinteractionsbetweenitschargedNandCtermini,andbetweenitshydrophobicregionandtheCterminus,preventself-association.Theseinteractionsinhibittheformationofinsolubleinclusions,whicharethepathologicalhallmarkofParkinson’sdiseaseandmanyothersynucleinopathies.ThisreviewdiscusseshowtheseintramolecularinteractionsareinfluencedbythespecificenvironmentaSynisin.Wediscusshowcharge,pH,calcium,andsaltaffectthephysiologicalstructureofmonomericaSyn,andhowtheymayfavourtheformationoftoxicstructures.ThemoreweunderstandthedynamicconformationsofaSyn,thebetterwecandesigndesperatelyneededtherapeuticstopreventdiseaseprogression.
Description
Keywords
Journal Title
Trends in Biochemical Sciences
Conference Name
Journal ISSN
0167-7640
Volume Title
44
Publisher
Elsevier